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Department of Engineering, ICT and Technologies for Energy and Transport Patent Title PrŽcedure and sysƚem ĨŽr ƚŚe deƚermŝŶĂƟŽn ŽĨ eƉŝĐĂƌĚŝĂů Ĩaƚ vŽůƵŵe ĨƌŽŵ ƚŽŵŽŐƌĂƉŚŝĐ ŝŵĂŐes, and relĂƚĞd cŽmƉƵƚĞƌ ƉrŽŐƌĂŵ͘ ReĨ͘ CNR 10167 Assignee(s): CNR CNR InƐƟƚute(s): ISTI - IFC Main Inventor: Davide Moroni Countries: IT, EP, US Priority date: 17/01/2012 Abstract Ɖicardial ĨĂƚ quanƟĮcaƟŽn allŽǁs ƚŽ ŽďƚĂin an indeƉendenƚ and ŽďũecƟve ƉĂrameƚer ƚŚĂƚ can be useĨƵl ĨŽƌ ƉƌŽŐŶŽsƟĐ sƚƌĂƟĮĐĂƟŽn and ůŽŶŐŝƚƵdinal assessmenƚ ŽĨ cardŝŽǀĂƐĐƵůĂƌ risk͘ This is well ĚŽĐƵŵĞŶƚed in ƚŚe lŝƚerĂƚure and shŽǁŶ in several clinical ƚriaůƐ͘ TŽ dĂƚe, ƚŚere are ŶŽ reliable and reƉrŽĚƵĐŝďůe ŵĞƚhŽĚƐ ĨŽƌ ƚhe measuremenƚ ŽĨ ĞƉŝĐĂƌĚŝĂů ĨĂƚ vŽůƵŵĞ ƚhaƚ can be aƉƉůŝed in clinical ƉƌĂcƟĐĞ by ŵĂŬŝŶŐ use ŽĨ sƚandard cŽmƉƵƚĞd ƚŽmŽŐƌĂƉŚy scans͘ The Ɖresenƚ inveŶƟŽn Įůůs ƚŚis lack by ƉrŽvidinŐ an easy-ƚŽ-use ƉrŽĐedure ƚŚĂƚ ĂůůŽǁƐ an accurĂƚe and reƉƌŽĚƵĐŝďůe measuremenƚ ŽĨ eƉŝĐĂƌĚŝal ĨĂƚ vŽlume ĨƌŽm vŽůƵŵeƚƌic ŝŵĂŐes, such as ƚŽŵŽŐƌĂƉŚŝĐ imaŐĞs acquired wŝƚŚ Žr wŝƚhŽƵƚ cŽŶƚrĂƐƚ aŐenƚ adminisƚrĂƟŽŶ, includinŐ ƚŚŽse ŽďƚĂŝned in cŽmƉƵƚed ƚŽmŽŐƌĂƉŚy anŐŝŽŐƌĂƉŚy͘ Background Pericardial ĨĂƚ, like ŽƚŚer visceral ĨĂƚ deƉŽƚƐ, is reůĂƚed ƚŽ ŵĂũŽr carĚŝŽvascular and meƚabŽůŝc diseases and is cŽŶsidered ƚŽ be a siŐniĮcĂŶƚ marker ŽĨ ƚŚe assŽcŝĂƚed risk ĨĂcƚŽrƐ͘ Several clinical sƚƵĚŝes have demŽŶsƚƌĂƚed ƚhe imƉŽƌƚĂnce ŽĨ quanƟĮĐĂƟŽŶ ŽĨ eƉŝcardial ĨĂƚ, which aůůŽws ƚŽ ŽďƚĂin an indeƉendenƚ and ŽďũeĐƟve ƉĂƌĂmeƚer useĨul ĨŽr ƉƌŽŐŶŽsƟĐ sƚƌĂƟĮĐĂƟŽŶ and ůŽŶŐŝƚƵĚŝŶĂl assessmeŶƚ ŽĨ ĐĂƌĚŝŽvascular risk͘ Technology The inveŶƟŽn makes use ŽĨ a ĐŽŶveŶƟŽŶĂl ĐŽŵƉƵƚed ƚŽŵŽŐrĂƉŚy anŐŝŽŐrĂƉhy ƚŽ ŽbƚĂŝnan esƟŵĂƚe ŽĨ ƚhe ĞƉŝĐĂƌĚŝĂl ƐƵƌĨĂĐĞ by means ŽĨ a ƚŚree-dimensŝŽŶĂů mŽdel ŐenerĂƚed ĨrŽŵ a series exƉĂŶsŝŽn ŽĨ veĐƚŽr sƉŚerical ŚĂƌŵŽŶŝĐƐ͘ Then, ƚhe vŽlume ŽĨ cardiac ĨĂƚ is ĐŽŵƉƵƚed ŽŶ ƚŚe basis ŽĨ ƚŚe vŽxels ůŽĐĂƚed ǁŝƚŚŝŶ ƚŚe eƉŝĐĂƌĚŝĂů suƌĨĂĐe and ŚĂǀŝŶŐ an ĂƩeŶƵĂƟŽn level in ƚŚe ĐŚĂƌĂĐƚerisƟc ƌĂŶŐe ŽĨ adŝƉŽse ƟƐsue͘ Advantages and ApplicaƟons The ƉrŽĐedure makes ƉŽssible ƚŚe measuremeŶƚ ŽĨ eƉŝĐĂrdial Ĩaƚ vŽlume requirinŐ a minimum ŝŶƚerĂĐƟŽn wŝƚŚ ƚŚe user and is characƚerized by hiŐh reƉeĂƚĂbiliƚy, lŽw ŝŶƚer- and ŝŶƚra-Žbserver variabiůŝƚy and ŐŽŽd execuƟŽn sƉeed͘ /ƚ can be used in clinical ƉƌĂĐƟce, even by nŽŶ-medical ƉerƐŽŶŶel, alůŽwinŐ ƚhe sƚudy ŽĨ carĚŝŽvascular and ŵĞƚĂďŽůŝc diseases Žver lĂƌŐĞ ƉŽƉƵůĂƟŽŶƐ͘ Development stage A sŽŌware ƉĂĐkaŐĞ has been desiŐned and deveůŽƉed͘ Thanks ƚŽ a ŐƌĂƉhic user ŝŶƚerĨace, ŝƚ ĂůůŽǁs ƚŽ carry ŽƵƚ ƚŚĞ ĞŶƟƌĞ ƉƌŽcessinŐ and analysis ƉŝƉĞůŝŶĞ͘ The sŽŌǁĂƌĞ is ready ƚŽ be ŝŶƚĞŐrĂƚĞd ǁŝƚŚ exisƟŶŐ sƚandard-based ICT ŝŶĨrasƚƌucƚure ĨŽr healƚh such as RIS and PA ^͘ 63